Hyrimoz 40mg/0.4ml Injection In Pre-Filled Syringe 2 Pens (Box)

Hyrimoz 40mg/0.4ml Injection in Pre-Filled Syringe is a biosimilar biologic medicine belonging to the class of TNF-alpha inhibitors (tumour necrosis factor blockers), and its active ingredient is adalimumab. If you have been prescribed this medicine, it is important to know that it may cause some side effects such as injection site reactions, headache, upper respiratory tract infections, and in some cases, a higher risk of infections due to its effect on the immune system.

This is a prescription-only injectable medicine that comes ready to use in a pre-filled syringe, making it more convenient for patients in Singapore who self-administer at home under medical guidance. You should always use it exactly as your doctor has instructed, and never skip doses without checking with your healthcare provider first — staying consistent with your treatment schedule really does make a difference with this type of medicine.

The commonly recommended adult dose of Hyrimoz in Singapore is 40mg administered once every two weeks as a subcutaneous injection, though your doctor may adjust the frequency or dosage depending on your specific medical condition and treatment response. Always follow your prescribing doctor’s instructions precisely, as dosage may vary for different conditions and patient groups, including paediatric patients in Singapore.

Common Side Effects:

• Injection site reactions such as redness, swelling, itching, or pain at the injection site
• Upper respiratory tract infections (e.g. runny nose, sore throat, sinusitis)
• Headache
• Nausea
• Rash or skin reactions
• Musculoskeletal pain (joint or muscle aches)
• Elevated liver enzymes detected in blood tests

Less Common Side Effects:

• Serious infections including bacterial, viral, or fungal infections
• Reactivation of latent tuberculosis (TB)
• Urinary tract infections
• Anaemia (low red blood cell count)
• Leucopenia (reduced white blood cell count)
• Hypersensitivity or allergic reactions including difficulty breathing, swelling of the face or throat
• Demyelinating disorders (rare neurological conditions)
• Worsening of heart failure in patients with pre-existing cardiac conditions
• Lupus-like syndrome (rare)
• New or worsening psoriasis (paradoxical reaction)
• Elevated blood lipid levels

• Store Hyrimoz in a refrigerator between 2°C and 8°C.
• Do not freeze the product — freezing will damage the medicine and render it unusable.
• Keep the pre-filled syringe in its original carton to protect it from light.
• If needed, Hyrimoz may be stored at room temperature (up to 25°C) for a maximum of 14 days, but once removed from the refrigerator, it must be used within this period or discarded.
• Keep out of reach and sight of children at all times.
• Do not store near direct sunlight or in a damp environment such as a bathroom cabinet.
• Dispose of used syringes safely in a sharps disposal container as instructed by your Singapore healthcare provider or pharmacist.

• Always keep Hyrimoz refrigerated between 2°C and 8°C — do not freeze it under any circumstances.
• Remove the syringe from the fridge 15–30 minutes before use to allow it to reach room temperature, which helps reduce discomfort during injection.
• Rotate your injection sites each time you administer the dose to help prevent skin hardening or irritation.
• Never shake the pre-filled syringe before use. Inspect the solution visually; it should be clear to slightly opalescent and colourless to slightly yellow.
• Do not use the syringe if the solution appears cloudy, discoloured, or contains visible particles.
• Inform all your healthcare providers, including dentists and surgeons in Singapore, that you are using Hyrimoz before undergoing any medical or dental procedure.
• Get tested for TB and other infections before starting treatment, as recommended by your doctor.
• Dispose of used syringes safely in an approved sharps container according to Singapore's local disposal recommendations. Never dispose of them in regular household waste.
• Do not share your pre-filled syringe with anyone else, even if they have the same condition.
• Store the medicine in its original carton to protect it from light until the time of use.

Hyrimoz 40mg/0.4ml Injection in Pre-Filled Syringe has a shelf life of 24 months (2 years) from the date of manufacture when stored under the recommended conditions. Always check the expiry date printed on the outer carton and the pre-filled syringe label before use, and never use the product if it has passed its expiry date.

The active ingredient in Hyrimoz 40mg/0.4ml Injection is Adalimumab 40mg per 0.4ml.

Adalimumab is a fully human monoclonal antibody that works by targeting and neutralising TNF-alpha (tumour necrosis factor-alpha), a protein involved in inflammatory processes in the body. It is classified as a biosimilar to the reference biologic medicine Humira® and has been approved based on demonstrated biosimilarity in terms of quality, safety, and efficacy.

• Active tuberculosis (TB) or other severe active infections such as sepsis or opportunistic infections
• Known hypersensitivity to adalimumab or any of the excipients in the formulation
• Moderate to severe heart failure (NYHA Class III/IV)
• Patients with active hepatitis B infection who have not received appropriate antiviral treatment
• Immunocompromised patients with conditions that significantly increase infection risk, unless carefully evaluated by a specialist
• Use in children under the age specified for each approved indication — dosing in paediatric patients must be guided strictly by a specialist physician

Hyrimoz must only be prescribed and initiated by a qualified specialist physician with experience in diagnosing and treating the relevant condition in Singapore. Always disclose your full medical history, including any history of infections, cancer, or neurological conditions, to your doctor before starting treatment.

Drug Interactions

• Live vaccines — Hyrimoz should not be administered alongside live vaccines (e.g. BCG, yellow fever vaccine) as there is a risk of serious or fatal infections.
• Anakinra (IL-1 inhibitor) — Concurrent use with anstrong> — Combination use with abatacept and other biologic DMARDs is generally not recommended due to increased infection risk.
• Methotrexate — Commonly co-prescribed with adalimumab; while generally considered acceptable under medical supervision, close monitoring for side effects is required.
• Other immunosuppressants (e.g. azathioprine, ciclosporin) — May increase the risk of infections and malignancies when used together; requires careful medical oversight.
• Other TNF inhibitors — Should not be used concurrently with other TNF-blocking agents.

There are no known clinically significant food interactions with Hyrimoz. However, maintaining a balanced diet and a healthy immune system is generally encouraged during biologic therapy. Avoid consuming grapefruit or grapefruit juice if you are on other concurrent medications that may interact with it — always check with your Singapore pharmacist.

1. Can I purchase Hyrimoz 40mg/0.4ml Injection online in Singapore?
Yes, Hyrimoz 40mg/0.4ml Injection in Pre-Filled Syringe is available for purchase through our licensed online pharmacy in Singapore. As this is a prescription medicine, you will be required to provide a valid prescription from a registered medical practitioner before your order can be processed and dispatched.

2. Do I need a prescription to order Hyrimoz in Singapore?
Yes, absolutely. Hyrimoz (adalimumab) is a prescription-only medicine (POM) in Singapore and cannot be legally dispensed without a valid prescription. When placing your order with us, you will need to upload or submit a copy of your doctor's prescription. This is a regulatory requirement and also ensures your safety as a patient.

3. How do I know the Hyrimoz I am purchasing online is authentic and not counterfeit?
We understand that authenticity is a top concern when purchasing biologic medicines online. Our pharmacy sources Hyrimoz directly from authorised pharmaceutical distributors and licensed suppliers in Singapore. All products sold through our platform are registered with the Health Sciences Authority (HSA) Singapore and come with intact original packaging, batch numbers, and expiry dates for your verification.

4. Does your online pharmacy deliver Hyrimoz across Singapore?
Yes, we deliver Hyrimoz to addresses across Singapore. Because Hyrimoz requires cold-chain storage, we use temperature-controlled packaging and cold-chain delivery to ensure the medicine arrives safely and within the required storage conditions.

5. How is Hyrimoz kept cold during delivery?
We take cold-chain integrity very seriously. Hyrimoz is packed with insulated cold packaging and ice packs or gel coolants to maintain the required temperature of 2°C to 8°C throughout the delivery journey. We recommend being available to receive your order promptly and placing it in your refrigerator immediately upon arrival.

6. What should I do when my Hyrimoz order arrives?
As soon as your Hyrimoz delivery arrives, check the packaging for any signs of damage, verify the expiry date, and place the pre-filled syringe(s) in your refrigerator immediately. If you notice any damage to the packaging, discolouration of the solution, or any concerns about the product, contact our customer service team right away and do not use the product.

7. How long does delivery of Hyrimoz take within Singapore?
Delivery timeframes may vary depending on your location within Singapore. Generally, we aim to deliver within 5 to 7 working days. We will provide you with a tracking number once your order has been dispatched so you can monitor your delivery.

8. Can I order Hyrimoz in advance to ensure I never run out of my supply?
Yes, and we actually encourage patients on long-term biologic therapy to plan ahead and order in advance to avoid any interruptions in treatment. Our team can assist you with managing your repeat prescription orders. Please ensure you have a valid and current prescription each time you reorder.

9. What payment methods are accepted when ordering Hyrimoz online in Singapore?
We accept a range of secure payment methods including major credit and debit cards, PayNow, and other commonly used payment options in Singapore. All transactions are processed through a secure payment gateway to protect your personal and financial information.

10. Is my personal and medical information kept confidential when I order online?
Yes, your privacy is our priority. All personal data, prescription information, and order details are handled in strict accordance with Singapore's Personal Data Protection Act (PDPA). We do not share your information with third parties without your consent.

11. What should I do if I receive the wrong product or a damaged item?
If you receive an incorrect product or one that appears damaged upon delivery, please contact our customer service team immediately with your order details and photographs of the item. We will arrange for a replacement or resolution as quickly as possible in line with our returns and quality assurance policy.

12. Can I get a pharmacist consultation before purchasing Hyrimoz online?
Yes, our licensed pharmacists are available to answer any questions you may have regarding your prescription, storage, handling, or ordering process. You can reach us via our website chat, email, or phone. We are here to make sure you feel confident and well-supported throughout your purchase journey.

Hyrimoz is administered as a subcutaneous injection, meaning it is injected just under the skin, typically into the abdomen or thigh area. Your Singaporean doctor or nurse will show you the correct technique before you begin self-administering at home, and it is important to rotate injection sites each time to avoid skin irritation. Always allow the pre-filled syringe to reach room temperature before use and follow the full administration instructions provided in the patient information leaflet supplied with your medicine.